Endophytic fungi produce important bioactive primary and secondary metabolites. Researchers used L-Asparaginase for the treatment of Acute Lymphoblastic leukemia (ALL). Endophytic taxon, Lasiodiplodia theobromae (Pat.) Griff. and Maubl. has been isolated from Teucrium polium plant tissues collected from Saint Katherine Protectorate and was screened for its ability to produce L-Asparaginase qualitatively and quantitatively. The crude enzyme has been partially purified using gel-filtration Sephadex G-100 with an activity of 21.00 lMmL-1 min-1. The results revealed that L. theobromae (SCUF-TP2016) represents a rich source of bioactive metabolites that can be manipulated to produce L-Asparaginase which is a desirable novel analog for chemotherapy.
(2018). Production of L-Asparaginase (L-ASN) from endophytic Lasiodiplodia theobromae hosted Teucrium polium in Egypt. Microbial Biosystems, 3(2), 46-55. doi: 10.21608/mb.2018.26276
MLA
. "Production of L-Asparaginase (L-ASN) from endophytic Lasiodiplodia theobromae hosted Teucrium polium in Egypt", Microbial Biosystems, 3, 2, 2018, 46-55. doi: 10.21608/mb.2018.26276
HARVARD
(2018). 'Production of L-Asparaginase (L-ASN) from endophytic Lasiodiplodia theobromae hosted Teucrium polium in Egypt', Microbial Biosystems, 3(2), pp. 46-55. doi: 10.21608/mb.2018.26276
VANCOUVER
Production of L-Asparaginase (L-ASN) from endophytic Lasiodiplodia theobromae hosted Teucrium polium in Egypt. Microbial Biosystems, 2018; 3(2): 46-55. doi: 10.21608/mb.2018.26276
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