Marine collagen in advanced wound dressing technologies: Innovations and applications for healing

Document Type : Reviews

Authors

Department of Botany and Microbiology, Faculty of Science, Alexandria University, Alexandria, Egypt

Abstract

Collagen is a fibrous, triple-helical structure protein that plays a crucial role in our bodies. It is considered the most common protein in vertebrates and is found in various types distributed across different organs. Collagen offers numerous advantages, including ease of processing, biodegradability, hydrophilicity, and anti-ageing properties. It is also known to enhance tissue regeneration. Although synthetic collagen can be obtained, it is often not used due to its high cost and associated disadvantages. Instead, collagen is sourced from natural origins such as porcine, bovine, rodent, and marine sources. Among these, marine collagen is widely favored for its safety and non-toxic nature. This review focuses on the application of collagen in wound healing, specifically its use as a wound dressing to accelerate the four stages of the healing process by promoting cell migration and skin regeneration, particularly in chronic wounds. We will emphasize marine collagen due to its advantages as being safe, biodegradable, abundant, and low cost, that has been used in the manufacturing of scaffolds and their role in increasing wound healing rates. The manufacturing of scaffolds from various marine sources has demonstrated a significant effect on wound healing acceleration than normal wound dressings. Different types of scaffolds, including surgically applied scaffolds, sponges, and hydrogel scaffolds loaded with drugs, have also been explored for their effectiveness. The scaffolds loaded with the drug have the highest wound-healing acceleration rate.

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History

  • Receive Date: 24 August 2024
  • Revise Date: 19 October 2024
  • Accept Date: 11 November 2024

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