Document Type : Original Article
Authors
1
Biomedical Engineering Department, University of Technology, Baghdad, Iraq.
2
Chemistry Department, College of Education for Pure Science, University of Kirkuk, Kirkuk, Iraq.
3
Department of Biology, College of Science, Mustansiriyah University, Baghdad, Iraq.
4
Department of Biology, College of Science, University of Baghdad, Baghdad, Iraq.
5
Department of Applied Science, University of Technology, Baghdad, Iraq.
Abstract
The use of metal oxide nanoparticles, especially zinc oxide, in medicine is crucial because of their antifungal properties as well as their physical and chemical properties. Using a biological approach, this study sought to examine the in vitro activity of zinc oxide nanoparticles against Candida albicans in leukemia patients. The characterization of the zinc oxide nanoparticles was done using X-ray Diffraction instrument (XRD) and Fourier transform infrared spectroscopy. The synthesized nanoparticles' capacity to suppress human Candida albicans isolated from leukemia patients could be accomplished by the Sabouraud Dextrose Agar technique, and they could be distinguished using the API Candida albicans, CHROM Candida agar, and germ tube test. Zinc oxide's antifungal properties against Candida albicans were examined. Fifty samples of Candida albicans showed resistance to fungal activity after being tested for sensitivity to several kinds of fungal antibiotics. At zinc oxide nanoparticle concentrations of 400, 200, 100, and 50 mg/ml, respectively, Candida albicans inhibition zones had widths of 11, 12, 12, and 10 mm; at low concentrations of 25 mg/ml, no inhibition zones were seen. This study explores the potential of green-produced zinc oxide nanoparticles as strong antifungal agents against Candida albicans.
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