Antifungal potential of Senna alexandrina leaves against fungal strain Trichosporon inkin in vitro

Eldaly, Alaa El-deen Ebrahim; El-Sabagh, Sabha; El-Badry, Anwer S.; Ahmed, Amany A. M.

doi:10.21608/mb.2025.357317.1247

Antifungal potential of Senna alexandrina leaves against fungal strain Trichosporon inkin in vitro

Document Type : Original Article

Authors

¹ Botany and Microbiology Department, Faculty of Science, Menoufia University, Shebin El‑Kom, Egypt.

² Botany and Microbiology Department, Faculty of Science, Tanta University, Tanta, Tanta 31527, Egypt

10.21608/mb.2025.357317.1247

Abstract

Fungal skin infections have become a significant problem for people of all genders. Therefore, accurate diagnosis and treatment of the active disease, as well as the reduction of re-infection by continuing screening, following up with relatives, treating symptomatic carriers, and disinfecting their environment, are mandatory. Patients with health problems especially intensive care patients with weak immune systems need antifungal therapy without any side effects and without systemic treatment which may cause gastrointestinal symptoms, Chapped lips, nausea and vomiting, headache, Hypokalemia (low potassium levels in the blood), depression, cardiac toxicity, cardiac arrest, hepatotoxicity by elevation of liver enzymes and inflammation of liver and reduction of bile flow from the liver So this type of patients in pretty need of antifungal agents without all side effects that may arise by using commercial antifungal agents as Polyene macrolides , various Azloles, Allyamines , Griseofulvin, flucytosine. Studies have shown that the best alternative compounds for antifungal therapy are derived from plants and are effective with no side effects. Which don't add any physiological pressure on the pathogens to develop drug resistance, and are easily degradable. This article evaluates the antifungal activity of Senna alexandrina leaf extract using different solvents against the fungal strain Trichosporon inkin in vitro.

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