The role of Epstein - Barr virus and some immunological parameter in Multiple Sclerosis Iraqi patient

Document Type : Original Article

Authors

1 University of Baghdad

2 University of Baghdad-College of Science-Biology Dept.

10.21608/mb.2025.367781.1269

Abstract

Multiple Sclerosis (MS) is auto immune neuro inflammatory and neurodegenerative disease that infected and destroyed the central nerves system (CNS). Many variables influence start of multiple sclerosis disease. MS was thought to be caused by virus infection, particularly infection with Epstein-Barr virus (EBV) and other viruses. The aim of present study was to investigate the relationship between EBV and multiple sclerosis disease. Sixty blood sample were drawn from patients with (MS) Ranging in age from 18-75 years (from October 2024 to February 2025). The medical personnel of Dr. Saad Al-Witry Hospital for Neurosciences provided diagnoses for these patients. Thirty-five specimens of apparently healthy individuals were studied as a control group. All the studied groups were carried out to measure the level of EBV- CA IgG Ab and EBV- NA IgG Ab and some immunological parameters IL-10, IL-32 and neurofilament light chain (NfL) by Enzyme linked immunosorbent assay (ELISA) technique. The statistical analysis shows a highly significant difference(p<0.01) in the level of anti EBV IgG Ab (EBV-CA and EBV-NA) in sera of patients with MS and EBV compared to control groups. Also, the statistical analysis shows highly significant differences (p<0.01) in the level of (IL-10 and IL-32) in sera of patients with MS and EBV compared to control group. Highly significant difference (p<0.01) showed in the level of Neurofilament light chain (NfL) in sera of patients with MS and EBV compared to control group. The present study showed that EBV play important role as trigger factor for multiple sclerosis.

Keywords

Files

History

  • Receive Date: 12 March 2025
  • Revise Date: 23 April 2025
  • Accept Date: 20 August 2025

Share

How to cite

Statistics